Evidence-Based Practice (EBP) is the thoughtful integration of the best available research evidence coupled with clinical expertise and patient values (Sackett D, 1996).
EBP requires clinicians to develop a set of research-based skills including efficient searching of clinical literature and the assessment the best current evidence.
PICO is an acronym to help you remember the components of a focused research question! The question needs to identify the key problem of the patient, what treatment you are considering for the patient, what alternative treatment is being considered (if any) and what is the outcome you want to avoid or promote.